Acetoacetic acid sodium salt

Name	Acetoacetic acid sodium salt
Synonyms	Arbidol Impurity 45 Sodium 3-oxobutanoate sodium 2-acetoxyacetate ACETYLACETICACID,SODIUMSALT Acetoacetic acid sodium salt 3-Oxobutyric acid sodium salt 3-Oxobutanoic acid sodium salt Sodium Acetoacetate DISCONTINUED. Please see L469065.
CAS	623-58-5

Molecular Formula	C4H6O3
Molar Mass	124.07
Boling Point	52 °C(Press: 5 Torr)
Storage Condition	Room Temprature
Physical and Chemical Properties	Bioactive acetate acid sodium salt is a non-esterified fatty acid metabolite that is involved in the development of diabetes in humans. Acetic acid sodium salt induces oxidative stress and inhibits the assembly of very low density lipoprotein in bovine hepatocytes.
In vitro study	Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes.

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Acetoacetic acid sodium salt

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